You've had a miscarriage. Maybe more than one. And you've been told to keep trying.
Perhaps it was said kindly. Perhaps your doctor explained that miscarriage is very common, that one in four pregnancies ends this way, that it's usually "just one of those things," and that your body will sort itself out. Perhaps you were told to give it a few months and come back if it happens again.
And so you went home with your grief, your questions, and no answers.
I want to talk about that gap, because it's one I see all the time, and because you deserve to know what's possible.
"Common" does not mean uninvestigable
Miscarriage is common. That is true. But common does not mean inevitable, and it certainly does not mean uninvestigable.
The fact that something happens to many people is not a reason to stop asking why it happened to you. If anything, it's a reason to take it more seriously. Patterns that show up often are exactly the kind that research can illuminate, that investigation can identify, and that support can address.
When "it's common" is accepted as a full answer, the conversation closes before it has really begun. That is not a failing of any one person. It is a gap in how the system is set up, and it is a gap that leaves women carrying questions alone.
There are meaningful, investigable factors that contribute to miscarriage. Some are embryonic. Some are maternal. Some, and this is the part that rarely gets said out loud, are on the paternal side. Recurrent miscarriage testing, done well, is not a single blood test and a reassuring follow-up. It is a considered look at both partners, at the pregnancy itself where possible, and at the environment in which conception is trying to happen.
"I don't want to chase symptoms. I want to understand the why."
A sentence I hear from so many women.
What investigation on her side can include
A standard post-miscarriage workup, when it is offered at all, often covers the basics: clotting factors, a uterine scan, perhaps a hormone panel. This is a starting point, not a destination. There is more worth asking about, and a practitioner working alongside your medical team can help you map it.
- Thyroid function: a full panel, not just TSH on its own. Thyroid hormones play a direct role in implantation and early pregnancy. A TSH that sits within the "normal" range may still be less than ideal for fertility. Free T3, free T4 and thyroid antibodies are all relevant.
- Autoimmune markers: particularly antiphospholipid antibodies, which are associated with recurrent pregnancy loss and clotting risk in early pregnancy. This is a well-established area that is sometimes not looked at until a third loss. It should not take three losses to get here.
- Natural killer (NK) cells: there is emerging evidence around elevated uterine NK cell activity and implantation, though this remains an evolving space. It is worth a conversation with a clinician who specialises in recurrent loss.
- Nutrigenomic factors, including methylation: MTHFR is one piece of this picture (more on that below). Methylation more broadly, the body's ability to process folate, recycle homocysteine and support cellular repair, is a legitimate consideration in the context of recurrent loss.
- The reproductive microbiome: there is growing evidence that the uterine and vaginal microbiome plays a role in implantation and early pregnancy. It is not yet standard in routine investigation, but it is worth knowing about and raising with your care team.
None of these are about finding something to blame. All of them are about understanding the environment a pregnancy is trying to grow in.
What investigation on his side should include
This is where I need to be direct, because this is where the gap in standard care is widest.
Half of the fertility equation involves him.
A standard semen analysis tells you about sperm count, movement and shape. It does not tell you about DNA integrity. Sperm DNA fragmentation and miscarriage have a well-documented relationship: higher fragmentation can affect embryo development and early pregnancy. And yet this test is not routinely included in a standard analysis.
A sperm sample can pass a standard analysis comfortably and still carry levels of DNA fragmentation that matter. This is not fringe science. It has been in the research for over a decade. It is simply not on the standard checklist, and it should be.
If your partner has not had sperm DNA fragmentation testing, it is worth raising with your care team. The question of what to test after recurrent loss is not complete until both partners have been meaningfully assessed.
The foetal testing conversation
Here is something that is genuinely hard to sit with.
When a miscarriage occurs, the pregnancy tissue contains information. Chromosomal analysis of the pregnancy can show whether a chromosomal difference was present, and critically, what kind. That distinction changes where you look next.
If different chromosomal differences are found
A single trisomy (one extra chromosome) is a relatively common error and, on its own, may be a chance event. But if you have had two or three losses and each one shows a different trisomy, that pattern of random errors can point toward the quality of the eggs or sperm at the time of conception. Oxidative stress, mitochondrial function and sperm DNA integrity all influence how accurately chromosomes are sorted. This is where naturopathic and lifestyle support may have a role to play, always alongside medical investigation, as part of caring for the environment in which conception happens. It is something to discuss with your practitioner.
If the same difference keeps recurring
If the same chromosomal difference recurs across pregnancies, that is a different signal entirely. It warrants parental karyotyping (a chromosome test for both partners) to look for an inherited variant. This is a very different path to egg or sperm quality support, and it is only possible to tell the two apart if the pregnancies have been tested.
If the embryo was chromosomally normal
A chromosomally normal embryo that miscarried is a different picture again, and in some ways the most important to identify. It is not a story about chromosomes. It is a question about the environment that embryo was trying to settle into: the uterine lining, immune tolerance, hormonal support in early pregnancy, autoimmune activity, the microbiome, clotting risk. This is where a full workup of both partners becomes not just useful but essential.
This testing exists, and you are entitled to ask for it
It is available in Australia. It is not experimental. And yet it is rarely offered as routine, particularly after a first or second loss. I understand the pressures on healthcare systems, and protocols exist for reasons. But couples who have experienced two or three losses without a single pregnancy ever being tested are working, to some degree, in the dark. If foetal chromosomal testing was not discussed after your loss, you are entitled to ask about it. That conversation is available to you.
A note on methylation and MTHFR
The internet has given MTHFR an outsized reputation. It is sometimes held up as the single explanation for miscarriage, and sometimes dismissed entirely. The reality is more nuanced.
MTHFR variants affect how efficiently the body processes folate and manages methylation. That has downstream effects on homocysteine, DNA methylation and cellular repair, all of which matter for embryo development. For some people this is clinically meaningful. For others it is not the main driver. MTHFR is one piece of the picture. It belongs in the conversation, held in proportion. One finding is never the whole story.
What to ask your healthcare team
- "Was foetal chromosomal testing an option after my miscarriage, and is it something we should consider?"
- "Can we look at a full thyroid panel, including antibodies?"
- "Has antiphospholipid syndrome been investigated?"
- "Has my partner had sperm DNA fragmentation testing?"
- "Is there merit in looking at methylation and nutrigenomic factors in my case?"
- "Is NK cell activity relevant given my history?"
These are reasonable, evidence-informed questions. A clinician who is genuinely engaged with your care will be willing to have these conversations, or to refer you to someone who can.
You deserve more than "keep trying"
There is a version of post-miscarriage care that is compassionate and thorough. That holds the weight of what has happened while also taking seriously the question of why. That looks at both partners. That does not require three losses before it starts looking.
That version of care exists. It may take some advocating to reach.
You are not asking for too much when you want to understand why. That is a legitimate question that deserves a real answer. The investigation of pregnancy loss is not a privilege. It is a conversation every couple deserves to be offered.
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For one-on-one investigation of recurrent loss, visit Fertility Support.
This article is for education only and does not replace individual medical advice, diagnosis or treatment. Every person's situation is different. Please speak with your healthcare professional about what is right for you.




